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School of Optometry and Vision Science

Current research

MRI of blood perfusion in the choroid

Patient going into MRI scanner, next to Safal Khanal PhD student and 1 other

This project investigates blood perfusion changes in the choroid in relation to eye growth regulation and myopia. Recent evidence suggests that the human choroid has a remarkable ability to modulate its thickness to compensate for imposed refractive error. However, mechanisms underlying these changes remain elusive. We are investigating the effects of optical and pharmacological interventions on the human choroid, and measuring thickness and blood perfusion changes using novel non-invasive techniques, such as optical coherence tomography (OCT) and arterial spin labelling magnetic resonance imaging (MRI).  

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Atropine control of myopia

Diagram relating to Myopia

This project investigates the mechanisms underlying atropine control of eye growth and myopia. Nightly instillation of atropine is the most successful treatment for inhibiting myopia progression at present. However, the site and mode of atropine’s actions are yet to be understood. We are using immunohistochemical and electrophysiological techniques on animal models and humans to probe the mechanisms by which atropine exerts its anti-myopia effects.

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Light and myopia

Recent epidemiological research suggests that outdoor activity during childhood may protect against myopia development, but it is unclear which aspects of outdoor activity account for the effect. This project investigates the parameters of light exposure in relation to development of experimental myopia in an animal model.

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